鹅去氧胆酸

分析标准品,HPLC≥98%

Chenodeoxycholic acid

CAS号：474-25-9

分子式：C24H40O4

分子量：392.58

MDL：MFCD00064142

别名：脱氧鹅胆酸；鹅脱氧胆酸；3α,7α-二羟基胆质酸；3α,7α-二羟基-5-β-胆烷酸

产品介绍

鹅去氧胆酸是一种疏水初级胆汁酸，能够活化核受体 FXR，该受体与胆固醇代谢有关。 生物活性：
Chenodeoxycholic Acid 是一种疏水初级胆汁酸，能够活化核受体 FXR，该受体与胆固醇代谢有关。鹅去氧胆酸（CDCA）和脱氧胆酸（DCA）均能抑制11 beta HSD2，IC50值分别为22mM和38mM，并引起皮质醇依赖性核易位，增加盐皮质激素受体（MR）的转录活性。鹅去氧胆酸能够通过激活膜G蛋白偶联受体（TGR5）依赖途径，诱导细胞周期蛋白d1蛋白和mRNA表达的显著增加，从而刺激Ishikawa细胞的生长。鹅去氧胆酸（CDCA）在培养的人肝母细胞瘤细胞系HepG2中诱导低密度脂蛋白受体mRNA水平约为4倍，高密度脂蛋白辅酶A还原酶和高密度脂蛋白辅酶A合成酶的mRNA水平为2倍。氯去氧胆酸诱导的ISC（≥67%）被布美他尼、Bacl2和囊性纤维化跨膜电导调节器（CFTR）抑制剂cftrinh-172抑制。腺苷酸环化酶抑制剂MDL12330A使鹅去氧胆酸刺激的ISC降低43%，鹅去氧胆酸增加细胞内cAMP浓度。鹅去氧胆酸处理激活c/ebpβ，如其磷酸化、核积累和在hepg2细胞中的表达增加所示。Chenodeoxycholic acid增强含有-1.65-kb GSTA2启动子的构建体的荧光素酶基因转录，该启动子含有C / EBP反应元件（pGL-1651）。鹅去氧胆酸处理激活AMP激活蛋白激酶（AMPK），导致细胞外信号调节激酶1/2（ERK1/2）激活，实验结果证明了使用AMPKα的显性负突变体和化学抑制剂。

熔点：165-167℃

沸点：547.1 ℃ at 760 mmHg

比旋光度：12 º (c=1, CHCl3)

外观：白色粉末

溶解性：几乎不溶于水，易溶于乙醇、冰乙酸、微溶于氯仿。

敏感性：对光敏感

储存条件：2-8℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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