穿心莲内酯

分析标准品,HPLC≥98%

Andrographolide

CAS号：5508-58-7

分子式：C20H30O5

分子量：350.45

MDL：MFCD07778082

产品介绍

熔点：229-232℃

沸点：557.3 ℃ at 760 mmHg

比旋光度：-126 º (c=1.5,HAc)

外观：白色方棱形或片状结晶 （乙醇或甲醇）

溶解性：易溶于甲醇、乙醇和丙tong，微溶于氯仿、乙mi，难溶于水、石油醚和苯。

储存条件：2-8℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(29篇)

29. [IF=3.8] Peng Wang et al."Andrographolide protects against the intestinal barrier dysfunction and inflammatory response through modulating ETEC virulence factors in a mouse model of diarrhea."Journal of Functional Foods.2024 Dec;123:106568

28. [IF=3.8] Xiu-mei Luan et al."Improvement of polarity-based solvent system for countercurrent chromatography in the guidance of solvent selectivity: n-hexane/ethyl acetate/ alcohol solvents/water as an example."JOURNAL OF CHROMATOGRAPHY A.2024 Nov;1736:465389

27. [IF=5.1] Zhou Xuebin et al."Andrographolide Improves ApoE4-Mediated Blood–Brain Barrier Injury by Alleviating Inflammation."MOLECULAR NEUROBIOLOGY".2024 Mar;:1-18

26. [IF=4.6] Kuo Yu et al."Integrating Transcriptome and Chemical Analyses to Provide Insights into Biosynthesis of Terpenoids and Flavonoids in the Medicinal Industrial Crop Andrographis paniculate and Its Antiviral Medicinal Parts."MOLECULES".2024 Jan;29(4):852

25. [IF=3.1] Liling Wang et al."In vitro and in vivo study of andrographolide nanoparticles for the treatment of Mycoplasma pneumoniae pneumonia."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2024 Jan;:149540

24. [IF=3.9] Ma Jianping et al."Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway."BMC Complementary Medicine and Therapies.2023 Dec;23(1):1-16

23. [IF=5.195] Yue Ju et al."Andrographolide exerts a neuroprotective effect by regulating the LRP1-mediated PPARγ/NF-κB pathway."EUROPEAN JOURNAL OF PHARMACOLOGY.2023 Jul;951:175756

22. [IF=5.223] Ming Chen et al."Andrographolide protects BMSCs from dexamethasone-induced cellular dysfunction and promotes bone formation via the PI3K/AKT pathway."Journal of Functional Foods.2023 Jun;105:105576

21. [IF=1.892] R.  Luo et al."Andrographolide restored production performances and serum biochemical indexes and attenuated organs damage in Mycoplasma gallisepticum-infected broilers."BRITISH POULTRY SCIENCE

20. [IF=3.571] Hong Jiang et al."Systematic identification of chemical components in Fufang Shuanghua oral liquid and screening of potential active components against SARS-CoV-2 protease."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Jan;223:115118

19. [IF=5.215] Jingya Liao et al."Andrographolide Promotes Uptake of Glucose and GLUT4 Transport through the PKC Pathway in L6 Cells."Pharmaceuticals.2022 Nov;15(11):1346

18. [IF=5.811]

17. [IF=4.932] Ronglong Luo et al."Andrographolide attenuates Mycoplasma gallisepticum-induced inflammation and apoptosis by the JAK/PI3K/AKT signal pathway in the chicken lungs and primary alveolar type II epithelial cells."INTERNATIONAL IMMUNOPHARMACOLOGY. 2022 Aug;109

16. [IF=2.441] Loureiro Damasceno et al.Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability.European Journal Of Drug Metabolism And Pharmacokinetics.2021 Nov 23

15. [IF=1.287] Xiaofei Li et al."Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells:."J Int Med Res. 2020;48(8):

14. [IF=4.101] Yan Li et al."Protective effects of andrographolide against cerebral ischemia‑reperfusion injury in mice."Int J Mol Med. 2021 Oct;48(4):1-13

13. [IF=0] Ying Liu et al."Andrographolide Induces Autophagic Cell Death and Inhibits Invasion and Metastasis of Human Osteosarcoma Cells in An Autophagy-Dependent Manner."Cell Physiol Biochem. 2017;44(4):1396-1410

12. [IF=2.311] Guo  Liu et al."Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells."Oncol Lett. 2018 Apr;15(4):5301-5305

11.  Liu, G., & Liu, G. (2018). Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells. Oncology Letters, 15, 5301-5305. https:##doi.org/10.3892/ol.2018.7941

10.  黄嘉玲,曾令杰,崔丹丹,陈远霞,张晓元,张浚凇.穿心莲等级与叶茎比、浸出物及内酯类成分之间的相关性[J].中成药,2020,42(10):2675-2679.

9.  曾吴静, 许玲, 何秋伶,等. 穿心莲农艺性状及其与二萜内酯成分相关性研究[J]. 中国中药杂志, 2019(15).

8.  邵艳华, 王建刚, 赖小平,等. 穿心莲二萜内酯类成分的高效薄层色谱指纹图谱研究[J]. 中药材, 2014, 37(2):219-223.

7.  邵晓婷, 张瑜, 郭择邻,等. 载穿心莲二萜内酯有效部位的透明质酸-苯硼酸纳米粒的制备[J]. 中成药, 2019, 041(011):2553-2560.

6.  孟慧, 许勇. 穿心莲内酯自乳化软胶囊的制备和溶出度评价[J]. 药学实践杂志, 2010, 28(3):184-185.

5.  王静娴, 李文, 陈婷,等. 穿心莲内酯纳米混悬剂的制备及评价[J]. 南京中医药大学学报, 2017, 33(003):313-316.

4.  魏东艳, 魏冬梅, 滕利. 穿心莲内酯对宫颈癌U14荷瘤小鼠抗肿瘤作用的影响[J]. 中成药, 2020, v.42(02):211-214.

3.  涂玉绮, 唐维平. 穿心莲内酯对人舌鳞癌Tca8113细胞增殖和凋亡的影响[J]. 重庆医学, 2014(14):67-69+72.

2.  魏东艳, 魏冬梅, 滕利. 穿心莲内酯对人宫颈癌SiHa细胞增殖、凋亡及细胞周期的影响[J]. 中国妇幼保健, 2019, 034(014):3341-3344.

1.  崔丹丹, 曾令杰, 黄嘉玲,等. 基于主成分聚类和PLS回归分析的穿心莲质量等级评价研究[J]. 中草药, 2019.

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