甘草次酸(β型）

分析标准品,HPLC≥98%

18β-Glycyrrhetinic acid

CAS号：471-53-4

分子式：C30H46O4

分子量：470.68

MDL：MFCD00003706

别名：18β-甘草次酸;(3β,18β)-3-羟基-11-氧代-齐墩果-12-烯-29-酸

产品介绍

18β-Glycyrrhetinic acid 是甘草的主要生物活性成分，具有抗溃疡，抗炎和抗增殖的特性。

熔点：292-295℃

沸点：588.3℃ at 760mmHg

比旋光度：165 o (C=1, CHCL3,ON DRY BA)

外观：白色结晶粉末

溶解性：DMSO  :  ≥  250  mg/mL  (531.15  mM)

储存条件：2-8℃

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参考文献(52篇)

52. [IF=4.1] Aijing Zhu et al."Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB Signaling Pathway."Journal of Inflammation Research.

51. [IF=5.4] Jianzeng Liu et al."Glycyrrhiza glabra Extract as a Skin-whitening Agent: Identification of Active Components and CRTC1/MITF Pathway-Inhibition Mechanism."JOURNAL OF ETHNOPHARMACOLOGY.2025 May;:119948

50. [IF=4.4] Yanjuan Zhang et al."Effects of Compound Probiotics on Pharmacokinetics of Cytochrome 450 Probe Drugs in Rats."DRUG METABOLISM AND DISPOSITION.2024 Nov;52(11):1297-1312

49. [IF=6.7] Xinguang Liu et al."Screening effective-component compatibility from Jinshui Chenfei formula for silicosis treatment by serum-pharmacochemistry and feedback system control."PHYTOMEDICINE.2025 Mar;138:156419

48. [IF=6.7] Yushu Wang et al."Honey-fried licorice in the treatment of arrhythmia: structure elucidation and the mechanism of antiarrhythmic activity."PHYTOMEDICINE.2024 Nov;:156259

47. [IF=6.7] Xiaoxiao Han et al."Integration of transcriptomics and metabolomics reveals the mechanism of Glycyrrhizae Radix Et Rhizoma extract inhibiting CCL5 in the treatment of acute pharyngitis."PHYTOMEDICINE.2025 Jan;:156360

46. [IF=2.6] Chenchen Song et al."18beta-glycyrrhetinic acid alleviates deoxynivalenol-induced hepatotoxicity by inhibiting GPX4-dependent ferroptosis."TOXICON.2025 Jan;:108228

45. [IF=4.9] Xiaoran Zhao et al."Constructing a hydrogel based on self-assembly properties of glycyrrhizic acid: A drug delivery system with digestive tract responsive."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2024 Sep;697:134497

44. [IF=4.2] Ting Lu et al."18β-Glycyrrhetinic acid synergizes with enzalutamide to counteract castration-resistant prostate cancer by inhibiting OATP2B1 uptake of dehydroepiandrosterone."EUROPEAN JOURNAL OF PHARMACOLOGY.2024 Sep;:176995

43. [IF=13.6] Junze Jiang et al."18β-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control."JOURNAL OF HAZARDOUS MATERIALS".2024 Jun;471:134319

42. [IF=5.4] Xinxin Wu et al."The therapeutic efficacy and mechanism action of Si Cao formula in the treatment of psoriasis: A pilot clinical investigation and animal validation."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117662

41. [IF=5.4] Yun Zhang et al."Investigation of the material basis and mechanism of Lizhong decoction in ameliorating ulcerative colitis based on spectrum-effect relationship and network pharmacology."JOURNAL OF ETHNOPHARMACOLOGY.2023 Dec;:117666

40. [IF=3.4] Wenmin Pi et al."Discovery, traceability, formation mechanism, metal and organic components analysis of supramolecules from Maxing Shigan decoction."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Sep;234:115532

39. [IF=3.4] Shu-ran Qin et al."Qualitative analysis on the transdermal absorption from the dichloromethane extract of the Sambucus adnata wall. based on UPLC-Q-Exactive Orbitrap/MS."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Sep;234:115509

38. [IF=12.7] Zhongyuan Li et al."Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage."JOURNAL OF MEDICAL VIROLOGY.2023 Aug;95(8):e29059

37. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

36. [IF=5.195] Zehua Jin et al."Network pharmacology study to reveal active compounds of Qinggan Yin formula against pulmonary inflammation by inhibiting MAPK activation."JOURNAL OF ETHNOPHARMACOLOGY.2022 Oct;296:115513

35. [IF=1.902] Yi Tao et al."A reliable LC–MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study."Biomed Chromatogr. 2019 Sep;33(9):e4570

34. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826

33. [IF=3] Tao-Guang HUO et al."Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury."Chin J Nat Medicines. 2020 Feb;18:138

32. [IF=3.361] Dan-Ni Feng et al."Green synthesis and characterization of gold nanoparticles and their application for the rapid detection of glycyrrhizin with immunochromatographic strips."Rsc Adv. 2021 Jul;11(39):23851-23859

31. [IF=3.365] Tao Yang et al."Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on 1H NMR metabonomics technology."Anal Biochem. 2021 Oct;631:114342

30. [IF=3.69] Qian Zhang et al."Qishen Granule alleviates endoplasmic reticulum stress-induced myocardial apoptosis through IRE-1-CRYAB pathway in myocardial ischemia."J Ethnopharmacol. 2020 Apr;252:112573

29. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002

28. [IF=4.36] Li Lin et al."Study on the alleviation of Fengshi Gutong capsule on rheumatoid arthritis through integrating network pharmacology and experimental exploration."J Ethnopharmacol. 2021 Nov;280:114471

27. [IF=4.749] Bin Wei et al."Highly Selective Entrapment of His-Tagged Enzymes on Superparamagnetic Zirconium-Based MOFs with Robust Renewability to Enhance pH and Thermal Stability."Acs Biomater Sci Eng. 2021;7(8):3727–3736

26. [IF=10.479] Jing Guo et al."Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug."J Adv Res. 2021 Oct;:

25. [IF=3.205] Zhuangzhuang Li et al."Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction."J Chromatogr B. 2019 Jan;1105:15

24. [IF=4.36] Taoguang Huo et al."Plasma metabolomics study of the hepatoprotective effect of glycyrrhetinic acid on realgar-induced sub-chronic hepatotoxicity in mice via 1H NMR analysis."J Ethnopharmacol. 2017 Aug;208:36

23. [IF=5.64] Wu  Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466

22.  Tao, Yi, et al. "Comparative pharmacokinetic analysis of extracts of crude and wine-processed Dipsacus asper in rats by a sensitive ultra performance liquid chromatography–tandem mass spectrometry approach." Journal of Chromatography B 1036 (2016): 33-41.h

21.  Tao, Y, Jiang, E, Yan, J, Cai, B. A biochemometrics strategy for tracing diuretic components of crude and processed Alisma orientale based on quantitative determination and pharmacological evaluation. Biomedical Chromatography. 2020; 34:e4744. https:##doi.

20.  Yi Tao, Surun Huang, Guangming Yang, Weidong Li, Baochang Cai,

A simple and sensitive LC–MS/MS approach for simultaneous quantification of six bioactive compounds in rats following oral administration of aqueous extract and ultrafine powder of Astragalus p

19.  Tao, Yi, et al. "Determination of major components from Radix Achyranthes bidentate using ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry and an evaluation of their anti‐osteoporosis effect in vitro." Journal of

18.  Tao, Yi, et al. "Development and validation of an UHPLC–MS/MS approach for simultaneous quantification of five bioactive saponins in rat plasma: Application to a comparative pharmacokinetic study of aqueous extracts of raw and salt-processed Achyranthes bi

17.  Tao-Guang, H. U. O., et al. "Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury." Chinese journal of natural medicines 18.2 (2020): 138-147.https:##doi.org/10.1016/S1875-5364(20)30014-5

16.  Yi Tao, Dandan Su, Weidong Li, Baochang Cai, Pharmacokinetic comparisons of six components from raw and vinegar-processed Daphne genkwa aqueous extracts following oral administration in rats by employing UHPLC–MS/MS approaches, Journal of Chromatography B,

15.  Tao, Y, Huang, S, Yan, J, Cai, B. A reliable LC–MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study. Biomedical Chromatography. 2019;

14.  纪万里,周泽华,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏泻心汤化学成分[J].药物分析杂志,2020,40(10):1736-1750.

13.  程丽娜, 曹世杰, 曲明,等. 甘草主要成分改善L6大鼠成肌细胞胰岛素抵抗的机制[J]. 中国实验方剂学杂志, 2020(4).

12.  王胜超  张振凌  刘艳 等. 人中黄炮制前后6种化学成分的含量变化及其质量评价[J]. 中国实验方剂学杂志  2017  023(009):11-16.

11.  仲金秋, 曹玉珠, 徐宏江,等. 甘草酸二铵改善ConA致小鼠肝损伤的作用研究[J]. 天然产物研究与开发, 2018, 30(12):60-68.

10.  王泽 慈小燕 崔涛 魏滋鸿 张洪兵 刘睿 李亚卓 伊秀林 张铁军 谷元 武卫党 刘昌孝.不同药性成分对OAT4、URAT1抑制作用及对急性高尿酸血症小鼠血尿酸水平的影响[J].中草药 2019 50(05):1157-1163.

9.  盖亚男, 汪琼, 陈剑,等. 盾叶薯蓣4种皂苷含量的LC-MS/MS快速测定法[J]. 现代中药研究与实践, 2017(02):54-56.

8.  王艳蕾, 贾雨涵, 赵嘉涵,等. 甘草次酸对雄**黄致小鼠海马突触超微结构损伤的改善作用[J]. 吉林大学学报(医学版), 2019, 045(002):268-272.

7.  王立英, 刘雨萌, 金元宝,等. 甘草次酸对谷氨酸所致PC12细胞损伤的保护作用及其机理[J]. 华西药学杂志, 2013(04):24-27.

6.  方莹,张颖花,霍韬光,何俏,侯明山,姜泓,康廷国.微透析-HPLC测定甘草次酸对雄**黄染毒小鼠海马细胞外液中Cys和Hcy含量的影响[J].化学研究,2016,27(02):202-205.

5.  董月柳, 李雪莲, 陈江鹏,等. 多成分环境下甘草次酸肠吸收行为的研究[J]. 中草药, 2017(16).

4.  王胜超  张振凌  于文娜 等. 人中黄的HPLC指纹图谱及炮制机理初探[J]. 中药材  2017(05):83-87.

3.  封聪  霍韬光  王守云 等. LC-MS/MS测定小鼠肾脏中甘草次酸的含量[J]. 化学研究  2016(3):318-322.

2.  王守云  霍韬光  封聪 等. LC-MS/MS测定小鼠肝脏中甘草次酸含量[J]. 化学研究  2016  27(004):429-432.

1.  顾薇  毛春芹  袁晓莉 等. HPLC-ELSD法精确定量大鼠胆汁中牛磺胆酸的方法研究[J]. 生物技术世界  2015  000(011):17-18.